3CACA1 | Structural determination | Materials and Chemistry | S9 | ||||||
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Lessons : 15 h | TD : 0 h | TP : 0 h | Project : 0 h | Total : 15 h | |||||
Co-ordinator : Stephane Perrio |
Prerequisite | |
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Previous courses dedicated to NMR spectroscopy – 1st year (1M1AC4) : Structural analysis of molecules – 2nd year (2C1AD4) : Molecular spectroscopy |
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Course Objectives | |
Addressing 1D and 2D NMR from the perspective of the organic chemist and not the spectroscopy specialist (the minimum of theory) – A large part of this course consists in the analysis of spectra, with in mind to describe correctly a compound in an experimental section. Determine a complex structure from a set of NMR data and assign all signals. Becoming familiar with modern and routine NMR techniques. | |
Syllabus | |
1 - Revision of the crucial knowledge in 1H and 13C NMR (chemical/magnetical équivalence, influence of symmetry elements, nomenclature of coupled spin systems, multiplet interpretation). 2 - 2D NMR (1H COSY, HMQC, HMBC, INADEQUATE, TOCSY, NOESY, HOESY, DOSY). 3 - 19F NMR. 4 - 31P NMR. 5 - Analytic approach for a full characterization of a compound, using a set of NMR spectra. | |
Practical work (TD or TP) | |
Some spectra are analyzed individually during the courses, or prepared as homework. Past exams provided. | |
Acquired skills | |
Knowledge of the modern and routine NMR (1D and 2D) experiments. Application to the full characterization of structurally diversified organic compounds. Interpretation and description of the spectra (experimental section, publication). | |
Bibliography | |
1) R. S. Macomber, A Complete Introduction to Modern NMR Spectroscopy, Wiley, New-York, 1998. 2) H. Friebolin, Basic One- and Two-Dimensional NMR Spectroscopy (5th, completely revised and updated edition), Wiley-VCH, Weinheim, 2011. 3) S. A. Richards, J. C. Hollerton, Essential practical NMR for organic chemistry, Wiley, Chichester, 2011. 4) O. Kühl, Phosphoros-31 NMR spectroscopy, Springer, Berlin, 2008. 5) W. R. Dolbier, Jr, Guide to fluorine NMR for organic chemists, Wiley, Hoboken, 2009. |
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