Module catalogue 2018/2019
| 2M1F1 | Chemistry of carbonylated compounds | Materials and Chemistry | S7 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Lessons : 14 h | TD : 10 h | TP : 0 h | Project : 0 h | Total : 24 h | |||||
| Co-ordinator : Jacques Rouden | |||||||||
| Prerequisite | |
|---|---|
| Basis of organic chemistry, main reactions, electronic effects, acids and bases (Bronsted and Lewis theory), Nucleophile and Electrophile Methods for characterization of organic compounds (NMR, IR, UV, mass spectro) Books : K.P.C. Vollhardt, N.E. Schore "Traité de Chimie Organique", Ed. DeBoeck, 4ème éd. (2004) J. McMurry, E. Simanek "Chimie Organique – les grands principes", Ed. Dunod, 2ème éd. (2007) |
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| Course Objectives | |
| Learn and understand the transformations (detailed mechanisms, specific cases) of carbonyl and carboxyl groups enabling the preparation of complexe organic compounds (natural products, agrochemical, drugs...) | |
| Syllabus | |
| 1-Introduction 2-Nucleophilic Additions(carbonyle groups) 3-Nucleophilic substitution on carboxyle groups 4-Reactions on the alpha postion of carbonyle : enol, enolate, enamine 5-Aldol, Mannich and Claisen reactions 6-Nucleophilic Additions on alpha,beta-unsaturated carbonyle 7-Ylides and carbonyle compounds 8-Miscelleneous reactions 9-Additional (List of rearrangements involving carbonyle and carboxyle groups, oxidations et reductions) |
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| Practical work (TD or TP) | |
| Tutorials : using the main knowledge learned with the course to solve problems of organic synthesis involving carbonylated and carboxylated fucntional groups | |
| Acquired skills | |
| Master the main tools (reactions, reagents, mechanisms, solvents) required to adress the multi-step synthesis of complex molecules | |
| Bibliography | |
| - Organic chemistry, J. Clayden, N. Greeves, S. Warren, P. Wothers, DeBoeck, 2003 - March'sAdvanced Organic Chemistry: Reactions, Mechanisms, and Structure, 6th Edition Michael B. Smith, Jerry March; Wiley Interscience (2007) - Advanced Organic Chemistry : structure and mechanisms (Part A) Francis A. Carey, Richard J. Sundberg, Ed. Springer (2008) - Advanced Organic Chemistry : Reactions and synthesis (Part B) Richard J. Sundberg , Francis A. Carey, Ed. Springer (2008) - Mécanismes Réactionnels en Chimie Organique Reinhard Brückner, Ed. De Boeck (1999) |
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