Module catalogue 2018/2019
| 2C2AC2 | Multi-step organic synthesis | Materials and Chemistry | S8 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Lessons : 18 h | TD : 0 h | TP : 0 h | Project : 0 h | Total : 18 h | |||||
| Co-ordinator : Jacques Rouden | |||||||||
| Prerequisite | |
|---|---|
| All courses related to organic chemistry of the previous semester | |
| Course Objectives | |
| Learn how to design and synthesize a complex molecule. Discuss the reaction mechanisms, the choice of reagent, the reaction conditions in the synthesis of a natural products | |
| Syllabus | |
| - Radical reactions - Oxidations - Reductions - Rearrangements and periccyclic reactions (see the related course on previous semester) - Total synthesis of natural products |
|
| Practical work (TD or TP) | |
| Tutorials : each student presents a well-known total synthesis of a natural product. He describes each steps, emphasizing on the reaction mechanisms. Exemples are taken from the organic chemistry literature of the 70's, 80's and 90's | |
| Acquired skills | |
| - Master the main strategies used in organic chemistry for the design and the synthesis of various and complex molecules | |
| Bibliography | |
| - Organic chemistry, J. Clayden, N. Greeves, S. Warren, P. Wothers, DeBoeck, 2003 - March'sAdvanced Organic Chemistry: Reactions, Mechanisms, and Structure, 5th Edition - Michael B. Smith, Jerry March; Wiley Interscience - Advanced organic chemistry : structure and mechanisms (Part A) Francis A. Carey, Richard J. Sundberg, 1997 - Advanced organic chemistry : reactinos and synthesis (Part B) Richard J. Sundberg , Francis A. Carey, 1997 - Classics in Total Synthesis, K. C. Nicolaou, E. J. Sorensen, Wiley, 1996 - The Logic of Chemical Synthesis, E. J. Corey, 1989 |
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